Assessment of the anti-HBV like property of BEHP – a phthalate derivative and its insilico characterization
نویسندگان
چکیده
Methods Fresh ink glands from Loligo duvauceli were dissected and the ink was subjected to crude solvent extraction. Chromatographic profiles were assessed by TLC and HPTLC. Fractionation of the bio active compounds was done by Silica gel column chromatography and the active fraction was subjected to GC-MS analysis. In vitro analysis of the anti-HBV like activity was assessed by pre incubating the HBV positive serum samples with the active fraction by performing ELISA. In silico virtual screening was analyzed with the latest bio informatics tools and databases.
منابع مشابه
Behp - a Phthalate Derivative Characterized from the South Indian Squid and Its Anti-hcv like Property: an In-vitro and In- Silico Analysis
Over decades, chronic infection with hepatitis C viruses results in liver cirrhosis, hepatocellular carcinoma and eventually, death. Many approved agents for treating viral hepatitis limits their efficacy as they manifest various side effects. Therefore, it is necessary to develop new antiviral drugs with fewer side effects, higher efficacy and with different modes of action against hepatitis v...
متن کاملIsolation and characterization of bis(2-ethylheptyl) phthalate from Cynodon dactylon (L.) and studies on the catalytic activity of its Cu(II) complex in the green preparation of 1,8-dioxo-octahydroxanthenes
Bis(2-ethylheptyl) phthalate is an anti-oxidant and anticancer compound that was extracted from the Cynodon dactylon plant stem extract and fully identified and characterized by FTIR, CHN, 1HNMR, 13CNMR, along with various 2D NMR techniques. The phthalate compound was modified and functionalized by polyethylene glycol (PEG) chains followed by complexation to Cu(II) ions. The resultant complex w...
متن کاملEvaluation of the Phthalate Esters in South Indian Women with Endometriosis
Background To evaluate the possible association between phthalate esters (PEs) and the occurrence of endometriosis. Blood samples were collected from 99 infertile women with endometriosis (study group); 135 age-matched women without endometriosis (control group) but with infertility related to tubal defects, fibroids, polycystic ovaries, idiopathic infertility and pelvic inflammatory diseases d...
متن کاملSynthesis and Characterization of Polyaniline-Polystyrene-Chitosan/Zinc Oxide Hybrid Nanocomposite
A hybrid nanocomposite composed of polyaniline-polystyrene-chitosan/zinc oxide was prepared via a simple in situ polymerization method. The synthesized copolymers were analyzed using Fourier Transform InfraRed (FT-IR), and UltraViolet-Visible (UV–Vis) spectroscopies, ThermoGravimetric Analysis (TGA), and Field Emission Scanning Electron Microscopy (FE-SEM), X-ray diffracti...
متن کاملChromatographic Characterization and GC-MS Evaluation of the Bioactive Constituents with Antimicrobial Potential from the Pigmented Ink of Loligo duvauceli
Chromatographic characterization and the GC-MS evaluation of the black pigmented ink of Loligo duvauceli in the present study have yielded an array of bioactive compounds with potent antimicrobial property. Facing an alarm of antimicrobial resistance globally, a need for elucidating antimicrobial agents from natural sources will be the need for the hour. In this view, this study is aimed at cha...
متن کامل